Rafael V C Guido Selected Research

DSM265

1/2021

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.

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Rafael V C Guido Research Topics

Disease

9	Malaria 01/2022 - 09/2014
3	Neoplasms (Cancer) 12/2021 - 05/2011
2	Infections 01/2022 - 01/2021
2	Leishmaniasis 08/2018 - 02/2014
2	Tuberculosis (Tuberculoses) 09/2013 - 06/2010
1	Dyslipidemias (Dyslipidemia) 01/2022
1	Obesity 01/2022
1	Body Weight (Weight, Body) 01/2022
1	Insulin Resistance 01/2022
1	Metabolic Diseases (Metabolic Disease) 01/2022
1	Nervous System Diseases (Neurological Disorders) 12/2021
1	Communicable Diseases (Infectious Diseases) 08/2021
1	Virus Diseases (Viral Diseases) 08/2021
1	COVID-19 08/2021
1	Cutaneous Leishmaniasis 01/2018
1	Visceral Leishmaniasis (Kala Azar) 01/2018
1	Chagas Disease (American Trypanosomiasis) 01/2018
1	Bone Resorption 01/2017
1	Osteoporosis 01/2015
1	Neoplasm Metastasis (Metastasis) 05/2011
1	Schistosomiasis (Bilharziasis) 09/2010
1	Parasitic Diseases (Parasitic Disease) 01/2009

Drug/Important Bio-Agent (IBA)

7	EnzymesIBA 01/2022 - 06/2010
7	Pharmaceutical PreparationsIBA 01/2022 - 01/2009
3	Antimalarials (Antimalarial Agents)IBA 01/2022 - 01/2019
2	LigandsIBA 02/2014 - 09/2013
2	Biological ProductsIBA 09/2013 - 05/2011
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	Triglycerides (Triacylglycerol)IBA 01/2022
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2022
1	Aryldialkylphosphatase (Paraoxonase)IBA 01/2022
1	StilbenesIBA 01/2022
1	glycylpeptide N-tetradecanoyltransferaseIBA 01/2022
1	ChromatinIBA 12/2021
1	Glutamic Acid (Glutamate)FDA Link 12/2021
1	Neurotransmitter Agents (Neurotransmitter)IBA 12/2021
1	GlutaminaseIBA 12/2021
1	Glutamine (L-Glutamine)FDA Link 12/2021
1	bothropstoxinIBA 08/2021
1	Peptides (Polypeptides)IBA 08/2021
1	Antiviral Agents (Antivirals)IBA 01/2021
1	VaccinesIBA 01/2021
1	Bortezomib (Velcade)FDA Link 01/2021
1	Dihydroorotate DehydrogenaseIBA 01/2021
1	pedalitinIBA 01/2021
1	DSM265IBA 01/2021
1	Superoxide DismutaseIBA 08/2018
1	Antiparasitic Agents (Antiparasitics)IBA 01/2018
1	PteridinesIBA 01/2017
1	Phosphopyruvate Hydratase (Enolase)IBA 02/2016
1	Heme (Haem)IBA 02/2016
1	Eukaryotic Initiation Factor-2 (EIF 2)IBA 02/2016
1	Biliverdine (Biliverdin)IBA 02/2016
1	hemozoinIBA 02/2016
1	ProtoporphyrinsIBA 02/2015
1	MetalloporphyrinsIBA 02/2015
1	protoporphyrin IXIBA 02/2015
1	Cathepsin KIBA 01/2015
1	2-octadecynoic acidIBA 09/2014
1	migrastatinIBA 05/2011
1	MacrolidesIBA 05/2011
1	purineIBA 09/2010
1	Purine NucleotidesIBA 09/2010
1	Protein Tyrosine PhosphatasesIBA 06/2010

Therapy/Procedure

3	Therapeutics 08/2021 - 09/2010
1	Oral Administration 01/2022
1	Drug Therapy (Chemotherapy) 01/2009